Safety Questions About NAD+ Infusions

Anyone thinking about an NAD+ drip should settle one thing first: what is actually known about it. This page walks through the safety questions in order, ending with when to stop and ask a professional.

Is it considered safe?

Healthline says that in general, intravenous NAD+ drips appear to be safe. It adds that NAD+ infusions are not approved by the federal drug regulator, which means their safety and efficacy have not been evaluated by it. A review of NAD⁺ biology and supplementation offers background on the compound.

What side effects have been listed?

Healthline lists possible side effects of NAD+ infusions as flushing, chest tightness, shortness of breath, palpitations, nausea, cramping and headache. It adds that slowing the infusion rate may help to manage these symptoms.

The National Library of Medicine (PMC) hosts a report in which participants who received intravenous NAD+ reported moderate to severe gastrointestinal symptoms, increased heart rate, and chest pressure during infusions. Participants receiving intravenous nicotinamide riboside experienced minor tongue, jaw, and arm tingling and mild cramping during infusion. All symptoms resolved upon infusion completion.

What about the long term?

Healthline states that there haven't been long-term studies on NAD+ infusions, so the long-term effects are not known. Readers comparing other intravenous products may find a systematic review of high-dose intravenous vitamin C a useful contrast in how risks and benefits get reported.

When to stop and ask

An infusion is not a home step. If chest tightness, palpitations or shortness of breath appear, stop and get qualified help. Before booking any session, ask a licensed professional what is in the bag, who monitors you, and who adjusts the rate.